Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL27544244 | 0.84 | MAPT (0.52) | RORCDRD2SLC6A4HTR6 | |
| Oxalic Acid SCHEMBL5365550 | 0.83 | MAPT (0.51) | RORCDRD2SLC6A4HTR6 | |
| Oxalic Acid SCHEMBL5365545 | 0.83 | MAPT (0.51) | RORCDRD2SLC6A4HTR6 | |
| SCHEMBL27452055 | 0.82 | RORC (0.47) | RORCDRD2SLC6A4SCN9ASCN5A | |
| SCHEMBL3260330 | 0.79 | DRD2 (0.44) | RORCDRD2SLC6A4SCN9ASCN5A | |
| SCHEMBL8602489 | 0.78 | DRD2 (0.43) | RORCDRD2SLC6A4SCN9ASCN5A | |
| Oxalic Acid SCHEMBL8605161 | 0.77 | CNR2 (0.42) | RORCDRD2KDM4EALDH1A1 | |
| SCHEMBL5367428 | 0.77 | CYP1A2 (0.57) | RORCDRD2SLC6A4HTR6 | |
| SCHEMBL3352752 | 0.77 | HTR1B (0.57) | RORCDRD2SLC6A4HTR6 | |
| SCHEMBL8606918 | 0.76 | DRD2 (0.44) | RORCDRD2HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066660-A | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |