Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 11/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL27544244 | 0.93 | MAPT (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| Oxalic Acid SCHEMBL5365545 | 0.92 | MAPT (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| Oxalic Acid SCHEMBL5365550 | 0.92 | MAPT (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL3352752 | 0.82 | HTR1B (0.57) | DRD2SLC6A4HTR6RORCHTR1B | |
| SCHEMBL9764630 | 0.82 | DRD2 (0.53) | DRD2SLC6A4HTR6RORCHTR1B | |
| SCHEMBL7645406 | 0.80 | DRD2 (0.57) | DRD2SLC6A4HTR6RORCHTR1B | |
| SCHEMBL27544243 | 0.79 | HTR6 (0.48) | DRD2SLC6A4HTR6RORC | |
| SCHEMBL5367153 | 0.79 | PLA2G2A (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| Water SCHEMBL5365547 | 0.78 | HTR6 (0.47) | DRD2SLC6A4HTR6RORC | |
| SCHEMBL27452055 | 0.78 | RORC (0.47) | DRD2SLC6A4HTR6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135484-A1 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | FILLA SANDRA A | 2007-06-14 | — | — | US | disclosed |
| US-7230011-B2 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht6 receptor | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1377580-B1 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2006-09-27 | — | — | EP | disclosed |
| CN-1275967-C | As 5-HT6Indol-5-yl benzenesulfonates as receptor antagonists | LILLY CO ELI (US) | 2006-09-20 | — | — | CN | disclosed |
| US-20040102481-A1 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-ht6 receptor | FILLA SANDRA ANN (US) | 2004-05-27 | — | — | US | disclosed |
| CN-1489591-A | As 5-HT6Indol-5-yl benzenesulfonates as receptor antagonists | — | 2004-04-14 | — | — | CN | disclosed |
| EP-1377580-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002060871-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102481-A1 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-ht6 receptor | HTR6, HTR5A, TPH1 | CYP1A2 973/4885CYP3A4 963/4885CYP2D6 89/4885 |
| US-20070135484-A1 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | HTR6, HTR5A, HTR7 | CYP1A2 996/4885CYP3A4 955/4885CYP2D6 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.