Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764850 | 0.79 | ALOX5 (0.51) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL10559844 | 0.78 | ALOX5 (0.50) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL10595601 | 0.76 | ALOX5 (0.45) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL9764842 | 0.76 | ALOX5 (0.48) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL10563662 | 0.74 | ALOX5 (0.46) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL8311679 | 0.72 | PKM (0.45) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL10560611 | 0.71 | PKM (0.45) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| Ammonia Solution, Strong SCHEMBL10595606 | 0.70 | PKM (0.44) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL10559326 | 0.70 | ALOX5 (0.39) | ALOX5PKMCYP2A6MAPTHDAC3 | |
| SCHEMBL7313877 | 0.70 | PKM (0.46) | ALOX5PKMCYP2A6MAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |