Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.41 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455483 | 1.00 | RORC (0.41) | RORCACSL1AKR1C3AKR1C1KDM4E | |
| SCHEMBL10454495 | 0.91 | RORC (0.40) | RORCACSL1KDM4EMAPTMAPK1 | |
| SCHEMBL10455777 | 0.90 | CCR3 (0.44) | RORCACSL1AKR1C3PDE4APDE4B | |
| SCHEMBL10455486 | 0.90 | RORC (0.41) | RORCACSL1PDE4APDE4BPDE4C | |
| SCHEMBL10455645 | 0.89 | BTK (0.41) | RORCAKR1C3AKR1C1PDE4APDE4B | |
| SCHEMBL10454522 | 0.88 | ACSL1 (0.48) | RORCACSL1ALOX15PDE4APDE4B | |
| SCHEMBL10455473 | 0.88 | KMT2A (0.44) | RORCMAPTMAPK1PDE4APDE4B | |
| SCHEMBL10455763 | 0.87 | RORC (0.41) | RORCACSL1AKR1C3AKR1C1PDE4A | |
| SCHEMBL10454493 | 0.86 | RORC (0.43) | RORCACSL1PDE4APDE4BPDE4C | |
| SCHEMBL10455787 | 0.86 | RORC (0.39) | RORCACSL1AKR1C3AKR1C1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210772-B1 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-06-06 | — | — | EP | claimed |
| US-4916147-A | 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid analogues and treatment of cerebral edema therewith | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-04-10 | — | — | US | claimed |
| EP-0210772-A2 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1987-02-04 | — | — | EP | claimed |
| US-5023268-A | Therapy for cerebral edema | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-06-11 | — | — | US | disclosed |
| EP-0231619-B1 | 3-PHENOXY(OR PHENYLTHIO)CYCLOPENTANECARBONYLAMINO ACID ANALOGUES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| EP-0210772-B1 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-06-06 | — | — | EP | disclosed |
| US-4916147-A | 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid analogues and treatment of cerebral edema therewith | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-04-10 | — | — | US | disclosed |
| US-4888351-A | TREATMENT OF CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-19 | — | — | US | disclosed |
| US-4829078-A | CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-05-09 | — | — | US | disclosed |
| US-4783476-A | 3-Phenoxy (or phenylthio)-cyclopentanecarbonylamino acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-11-08 | — | — | US | disclosed |
| EP-0231619-A2 | 3-Phenoxy(or phenylthio)cyclopentanecarbonylamino acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |
| EP-0210772-A2 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1987-02-04 | — | — | EP | disclosed |