Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | TKT | P29401 | 7/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PPP5C | P53041 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL478202 | 1.00 | LMNA (0.94) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19138210 | 0.99 | LMNA (0.93) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Phosphoric Acid SCHEMBL991151 | 0.99 | LMNA (0.93) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| SCHEMBL675863 | 0.99 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| SCHEMBL29465135 | 0.99 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| SCHEMBL9766253 | 0.99 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23151779 | 0.98 | LMNA (0.94) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Bromide SCHEMBL23151782 | 0.98 | LMNA (0.94) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL21111 | 0.98 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL8923435 | 0.98 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079576-A1 | A PROCESS FOR THE PREPARATION OF A THIAMINE DERIVATIVE AND SALT THEREOF | ASHMI LIFE SCIENCES PRIVATE LIMITED (IN) | 2016-05-26 | — | — | WO | claimed |
| WO-2016079576-A1 | A PROCESS FOR THE PREPARATION OF A THIAMINE DERIVATIVE AND SALT THEREOF | ASHMI LIFE SCIENCES PRIVATE LIMITED (IN) | 2016-05-26 | — | — | WO | disclosed |
| US-5047223-A | Separation of phosphoric acid from aqueous solutions of thiamine phosphates | BASF AKTIENGESELLSCHAFT (DE) | 1991-09-10 | — | — | US | disclosed |
| US-4999112-A | Using a Cation Exchanger Resin | BASF AKTIENGESELLSCHAFT (DE) | 1991-03-12 | — | — | US | disclosed |