Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976688 | 1.00 | ALOX5AP (0.40) | ALOX5APNPC1RAB9ASMN1; SMN2NAMPT | |
| SCHEMBL976566 | 0.91 | ALOX5AP (0.41) | ALOX5AP | |
| SCHEMBL976564 | 0.91 | ALOX5AP (0.41) | ALOX5AP | |
| SCHEMBL974876 | 0.87 | ALOX5AP (0.44) | ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL974874 | 0.87 | ALOX5AP (0.44) | ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL975719 | 0.86 | ALOX5AP (0.46) | ALOX5AP | |
| SCHEMBL12920600 | 0.86 | ALOX5AP (0.46) | ALOX5AP | |
| SCHEMBL977714 | 0.83 | ALOX5AP (0.54) | ALOX5AP | |
| SCHEMBL977715 | 0.83 | ALOX5AP (0.54) | ALOX5AP | |
| SCHEMBL12948116 | 0.80 | ALOX5AP (0.43) | ALOX5APSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003815-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | MERCK & CO., INC. | 2011-01-06 | — | — | US | disclosed |
| EP-2209761-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009048547-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | MERCK & CO., INC. (US) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003815-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | PTGIS, PTGS1, LTC4S | ALOX5AP 47/4885NPC1 721/4885RAB9A 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.