Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332334 | 0.78 | GRM2 (0.58) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL4096799 | 0.78 | GRM2 (0.58) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL4332336 | 0.78 | GRM2 (0.58) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL9633644 | 0.74 | GRM2 (0.47) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL4357223 | 0.72 | MMP13 (0.54) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL12209503 | 0.70 | HTT (0.52) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL10515747 | 0.69 | GBA1 (0.46) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4092499 | 0.69 | GRM2 (0.44) | GRM2HTTALDH1A1POLBRAB9A | |
| SCHEMBL3914346 | 0.69 | HTT (0.54) | GRM2HTTALDH1A1POLBMMP1 | |
| SCHEMBL13484174 | 0.68 | HPGD (0.47) | GRM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996224-A | 1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic method of use thereof | BOEHRINGER INGELHEIM KG (DE) | 1991-02-26 | — | — | US | disclosed |
| US-4767759-A | ANTIHYPOXICS | BOEHRINGER INGELHEIM KG (DE) | 1988-08-30 | — | — | US | disclosed |