Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9767748 | 0.99 | SIGMAR1 (0.65) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL9643179 | 0.87 | OPRK1 (0.82) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL7962880 | 0.87 | OPRK1 (0.82) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL9772344 | 0.86 | SIGMAR1 (0.61) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| Hydrochloric Acid SCHEMBL7077496 | 0.86 | OPRK1 (0.82) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL7963740 | 0.86 | OPRK1 (0.81) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| Hydrochloric Acid SCHEMBL9813887 | 0.86 | OPRK1 (0.82) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL9772623 | 0.86 | SIGMAR1 (0.61) | SIGMAR1OPRK1OPRM1OPRD1ALDH1A1 | |
| SCHEMBL9772473 | 0.86 | OPRK1 (0.81) | SIGMAR1OPRK1OPRM1OPRD1TP53 | |
| SCHEMBL5632066 | 0.83 | SIGMAR1 (0.57) | SIGMAR1OPRK1OPRM1OPRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272982-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-04-17 | — | — | EP | disclosed |
| US-4988727-A | Cardiovascular disorders, analgesics | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4888355-A | Indanes and their use as antiarrhythmic agents | ROUSSEL UCLAF (FR) | 1989-12-19 | — | — | US | disclosed |
| EP-0272982-A2 | Indane derivatives, process for their preparation and intermediates obtained, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-06-29 | — | — | EP | disclosed |