Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.37 |
| ▸ | GABRP | O00591 | 7/20 | 0.37 |
| ▸ | GABRD | O14764 | 7/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.37 |
| ▸ | GABRE | P78334 | 7/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9394102 | 0.80 | GABRB3 (0.44) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9768087 | 0.79 | P2RX7 (0.43) | ALDH1A1GABRB3GABRPGABRDGABRA1 | |
| SCHEMBL9768155 | 0.78 | GABRA2 (0.39) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9768229 | 0.78 | GABRA2 (0.41) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9768341 | 0.77 | GABRA2 (0.40) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9217807 | 0.76 | GABRA2 (0.41) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9219663 | 0.76 | GABRB3 (0.44) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9219343 | 0.75 | GABRA2 (0.40) | ALDH1A1GABRB3GABRPGABRDGABRA1 | |
| Methane SCHEMBL27278091 | 0.75 | GABRA2 (0.40) | GABRB3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9501605 | 0.73 | SMN1; SMN2 (0.40) | ALDH1A1GABRB3GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064844-A | Miticides | SCHERING AGROCHEMICALS LIMITED (GB) | 1991-11-12 | — | — | US | disclosed |
| CN-1039345-A | TRIAZOLE INSECTICIDES | SCHERING AGROCHEMICALS LTD (GB) | 1990-02-07 | — | — | CN | disclosed |