SCHEMBL9768869

SCHEMBL9768869

CCCCC(=NN)c1ccncc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
NAAA Q02083 1/20 0.41
GAA P10253 1/20 0.40
HTT P42858 2/20 0.39
LMNA P02545 5/20 0.38
NPC1 O15118 3/20 0.38
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2C9 P11712 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
HPGD P15428 1/20 0.37
STAT3 P40763 1/20 0.37
KDM4E B2RXH2 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9768797 0.89 KDM4E (0.38) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL9769034 0.81 ATM (0.42) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL21283419 0.79 SLC6A4 (0.44) HDAC3HDAC1HDAC2LMNASMN1; SMN2
SCHEMBL9769023 0.74 GAA (0.55) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL9769029 0.74 GAA (0.55) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL21283420 0.74 ALDH1A1 (0.49) HDAC3HDAC1HDAC2SMN1; SMN2KDM4E
SCHEMBL9768946 0.73 GPBAR1 (0.38) LMNACYP3A4CYP2D6CYP1A2CYP2C19
SCHEMBL7220547 0.72 HSD17B3 (0.63) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL7560833 0.72 HDAC3 (0.45) HDAC3HDAC1HDAC2NAAAGAA
SCHEMBL11072536 0.72 GPBAR1 (0.43) HDAC3HDAC1HDAC2NAAAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5011932-A Anthelmintic pyridinyl acylhydrazones derivatives UPJOHN COMPANY (US) 1991-04-30 US claimed
EP-0214158-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-03-18 EP claimed
WO-1986004582-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1986-08-14 WO claimed
US-5023334-A Anthelmintic pyridinyl acylhydrazones THE UPJOHN COMPANY (US) 1991-06-11 US disclosed
US-5011932-A Anthelmintic pyridinyl acylhydrazones derivatives UPJOHN COMPANY (US) 1991-04-30 US disclosed
EP-0214158-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-03-18 EP disclosed
WO-1986004582-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1986-08-14 WO disclosed