Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetarsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | PHPT1 | Q9NRX4 | 2/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetarsone SCHEMBL27369378 | 0.96 | POLB (0.76) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27475954 | 0.91 | POLB (0.88) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL29604580 | 0.91 | LMNA (1.00) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL156373 | 0.91 | LMNA (1.00) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27701891 | 0.90 | LMNA (0.97) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27571635 | 0.90 | LMNA (0.97) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL19947468 | 0.90 | LMNA (0.97) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27508847 | 0.90 | LMNA (0.97) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27363340 | 0.90 | LMNA (0.97) | POLBLMNAPHPT1SMN1; SMN2GAA | |
| Acetarsone SCHEMBL27416210 | 0.88 | POLB (0.88) | POLBLMNAPHPT1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024256742-A1 | ANTIDOTE | FUNDACIÓN PARA LA FORMACIÓN E INVESTIGACIÓN SANITARIAS DE LA REGIÓN DE MURCIA (ES) | 2024-12-19 | — | — | WO | disclosed |
| WO-2024175818-A1 | BRAKING DEVICE FOR AN ELECTRIC MOTOR | TECNIMUSA S.L. (ES) | 2024-08-29 | — | — | WO | disclosed |
| CN-118512668-A | Contraceptive medical device | 聚合-医药有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-114727953-B | Contraceptive medical device | 聚合-医药有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023166237-A1 | FERRULE FOR A GOLF FLAG STICK | MEDRANO LÓPEZ, Álvaro (ES) | 2023-09-07 | — | — | WO | disclosed |
| CN-115768895-A | Aptamers for the treatment of infections of the coronavirus family | 柏林制药股份有限公司 | 2023-03-07 | — | — | CN | disclosed |
| US-5001115-A | Prodrugs of biologically active hydroxyaromatic compounds | UNIVERSITY OF FLORIDA (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | disclosed |