Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597816 | 0.86 | HDAC1 (0.46) | HDAC1HDAC6F2F12ALDH1A1 | |
| SCHEMBL9770679 | 0.84 | LMNA (0.48) | HDAC1HDAC6ALDH1A1CXCR4MAPT | |
| SCHEMBL2688968 | 0.82 | HDAC1 (0.45) | HDAC1HDAC6F2F12P2RX7 | |
| SCHEMBL29640806 | 0.82 | HDAC1 (0.45) | HDAC1HDAC6F2F12P2RX7 | |
| SCHEMBL2305432 | 0.82 | HDAC1 (0.45) | HDAC1HDAC6F2F12P2RX7 | |
| SCHEMBL9770522 | 0.81 | HDAC1 (0.44) | HDAC1HDAC6HTTALDH1A1CXCR4 | |
| SCHEMBL27766407 | 0.79 | HDAC1 (0.44) | HDAC1HDAC6F2F12P2RX7 | |
| SCHEMBL27951689 | 0.78 | HDAC1 (0.46) | HDAC1HDAC6P2RX7CXCR4 | |
| SCHEMBL30558705 | 0.78 | HDAC1 (0.46) | HDAC1HDAC6ALDH1A1TSHRP2RX7 | |
| SCHEMBL3312236 | 0.78 | HDAC1 (0.46) | HDAC1HDAC6ALDH1A1TSHRP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101402537-B | Uses of 2-pyridine-beta ketone compounds | GUANGZHOU INST BIOMED & HEALTH | 2011-04-27 | — | — | CN | disclosed |
| CN-101402537-A | Uses of 2-pyridine-beta ketone compounds | GUANGZHOU INST BIOMED & HEALTH (CN) | 2009-04-08 | — | — | CN | disclosed |
| US-5001131-A | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1991-03-19 | — | — | US | disclosed |