Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695051 | 0.86 | TP53 (0.46) | PARP1PKMTP53TDP1PTGS2 | |
| SCHEMBL10696099 | 0.86 | PARP1 (0.44) | ELANEPARP1PKMPIK3CDTP53 | |
| SCHEMBL10697642 | 0.86 | ELANE (0.40) | ELANEPARP1PIK3CDTP53MAPT | |
| SCHEMBL10694920 | 0.83 | ELANE (0.47) | ELANEPKMMAPTKDM4EHPGD | |
| SCHEMBL9533044 | 0.80 | ELANE (0.40) | ELANEPARP1PIK3CDTP53PTGS2 | |
| SCHEMBL10694328 | 0.77 | ELANE (0.42) | ELANEPARP1TP53TDP1MAPT | |
| SCHEMBL9532203 | 0.77 | KDM4E (0.65) | ELANEPARP1PKMPIK3CDTP53 | |
| SCHEMBL9535817 | 0.74 | PARP1 (0.44) | ELANEPARP1PIK3CDTP53MAPT | |
| SCHEMBL9770718 | 0.73 | KDM4E (0.45) | ELANEPARP1PKMPIK3CDTP53 | |
| SCHEMBL10696516 | 0.72 | PARP1 (0.43) | ELANEPARP1PIK3CDTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5030727-A | Reacting an anthronilide derivative with a thiazole derivative or a fluorozuinazolone with a neucleophile | BASF AKTIENGESELLSCHAFT (DE) | 1991-07-09 | — | — | US | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |