Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696216 | 0.86 | PARP1 (0.44) | PARP1PDE7ATP53TDP1MAPT | |
| SCHEMBL10695331 | 0.86 | PDE7A (0.43) | ELANEPARP1PDE7APDE4APDE4B | |
| SCHEMBL10695759 | 0.83 | CYP1A1 (0.43) | PARP1KDM4EHPGDHSD17B10TNKS | |
| SCHEMBL9533693 | 0.80 | ELANE (0.40) | ELANEPARP1PDE7APDE4APDE4B | |
| SCHEMBL9532194 | 0.77 | KDM4E (0.65) | ELANEPARP1PDE7APDE4APDE4B | |
| SCHEMBL9770665 | 0.77 | ELANE (0.42) | ELANEPARP1TP53TDP1MAPT | |
| SCHEMBL10695623 | 0.73 | KDM4E (0.51) | ELANEPARP1PDE7APDE4APDE4B | |
| SCHEMBL10696717 | 0.72 | PARP1 (0.43) | PARP1PDE7ATP53MAPTKDM4E | |
| SCHEMBL9537313 | 0.71 | GAA (0.52) | ELANEPARP1PDE7APDE4APDE4B | |
| SCHEMBL9770629 | 0.70 | TNKS (0.42) | PARP1KDM4EHPGDHSD17B10TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |