Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535817 | 0.89 | PARP1 (0.44) | PARP1RXFP1MAPTPOLBTP53 | |
| SCHEMBL10696516 | 0.86 | PARP1 (0.43) | PARP1RXFP1MAPTPOLBTP53 | |
| SCHEMBL9770665 | 0.86 | ELANE (0.42) | PARP1RXFP1GAAPKMMAPT | |
| SCHEMBL10695051 | 0.83 | TP53 (0.46) | PARP1RXFP1GAAPKMMAPT | |
| SCHEMBL10694920 | 0.81 | ELANE (0.47) | RXFP1PKMMAPTPOLBELANE | |
| SCHEMBL9533229 | 0.80 | PARP1 (0.40) | PARP1RXFP1MAPTPOLBTP53 | |
| SCHEMBL10696216 | 0.78 | PARP1 (0.44) | PARP1RXFP1GAAMAPTPOLB | |
| SCHEMBL9533630 | 0.78 | KDM4E (0.62) | PARP1RXFP1PKMKDM4EHPGD | |
| SCHEMBL9770716 | 0.75 | PARP1 (0.44) | PARP1RXFP1PKMMAPTPOLB | |
| SCHEMBL10697642 | 0.72 | ELANE (0.40) | PARP1MAPTTP53ELANEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |