Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770566 | 0.82 | KDM4E (0.55) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770530 | 0.81 | KDM4E (0.57) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770534 | 0.81 | LMNA (0.47) | KDM4EGAAALDH1A1HPGDMAPT | |
| SCHEMBL9770630 | 0.78 | HSD17B10 (0.49) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770654 | 0.77 | KDM4E (0.56) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL4701242 | 0.74 | KDM4E (0.69) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770657 | 0.71 | KDM4E (0.49) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL3217857 | 0.70 | HPGD (0.59) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770626 | 0.68 | KDM4E (0.51) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL9770499 | 0.68 | KDM4E (0.45) | KDM4EGAAALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019574-A | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-05-28 | — | — | US | disclosed |
| EP-0361489-A2 | Novel 3,4-diaminoquinoline and pyridine compounds | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-04-04 | — | — | EP | disclosed |