Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770666 | 0.82 | KDM4E (0.49) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL9770560 | 0.80 | ALDH1A1 (0.54) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL9770654 | 0.79 | KDM4E (0.56) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL9770449 | 0.78 | CTSK (0.49) | KDM4ELMNAALDH1A1HTTMAPK1 | |
| SCHEMBL4701242 | 0.74 | KDM4E (0.69) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL9770630 | 0.72 | HSD17B10 (0.49) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9770657 | 0.72 | KDM4E (0.49) | KDM4ELMNAHPGDALDH1A1MAPT | |
| SCHEMBL1825303 | 0.72 | LMNA (0.97) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL2590824 | 0.72 | HTR2A (0.84) | KDM4ELMNAHPGDALDH1A1HTT | |
| SCHEMBL11915878 | 0.72 | KDM4E (0.49) | KDM4ELMNAHPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019574-A | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-05-28 | — | — | US | disclosed |
| EP-0361489-A2 | Novel 3,4-diaminoquinoline and pyridine compounds | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-04-04 | — | — | EP | disclosed |