Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MGMT | P16455 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770534 | 0.83 | LMNA (0.47) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL9770530 | 0.80 | KDM4E (0.57) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL9770553 | 0.75 | LMNA (0.51) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL14851001 | 0.74 | TLR9 (0.55) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9770634 | 0.73 | LMNA (0.53) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL9770560 | 0.72 | ALDH1A1 (0.54) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL1124006 | 0.72 | MAPT (0.55) | KDM4EMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9770640 | 0.70 | CTSB (0.54) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL3399391 | 0.70 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL9762334 | 0.69 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019574-A | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-05-28 | — | — | US | disclosed |
| EP-0361489-A2 | Novel 3,4-diaminoquinoline and pyridine compounds | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-04-04 | — | — | EP | disclosed |