Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927204 | 0.83 | MEN1 (0.32) | MEN1CYP1A2KMT2A | |
| SCHEMBL5918893 | 0.81 | PPARD (0.50) | TSHRTP53TDP1PPARDMEN1 | |
| SCHEMBL16352164 | 0.80 | MEN1 (0.34) | TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL16975426 | 0.78 | TSHR (0.40) | TSHRTP53TDP1PPARD | |
| SCHEMBL11293082 | 0.77 | CYP1A2 (0.40) | TSHRTDP1PPARDMEN1CYP1A2 | |
| SCHEMBL28029802 | 0.76 | TSHR (0.41) | TSHRTP53TDP1PPARDMEN1 | |
| SCHEMBL31503116 | 0.72 | MEN1 (0.32) | TSHRPPARDMEN1CYP1A2KMT2A | |
| SCHEMBL575221 | 0.72 | — | — | |
| SCHEMBL508153 | 0.71 | TSHR (0.50) | TSHRTP53TDP1PPARDMEN1 | |
| SCHEMBL28685599 | 0.71 | TSHR (0.54) | TSHRTP53TDP1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759818-B2 | Simple preparation method for dialkoxypropyl methylphosphonate | JIANGSU GOOD HARVEST-WEIEN AGROCHEMICAL CO., LTD (CN) | 2020-09-01 | — | — | US | disclosed |
| US-20190284215-A1 | SIMPLE PREPARATION METHOD FOR DIALKOXYPROPYL METHYLPHOSPHONATE | JIANGSU GOOD HARVEST-WEIEN AGROCHEMICAL CO., LTD (CN) | 2019-09-19 | — | — | US | disclosed |
| US-9139604-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2015-01-22 | — | — | US | disclosed |
| US-8871785-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110071101-A1 | Nucleoside Phosphonate Analogs | BOOJAMRA CONSTANTINE G | 2011-03-24 | — | — | US | disclosed |
| US-5075485-A | From acetal of methyl-(3-oxypropyl)phosphinic acid ester; chemical intermediate for herbicides | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |
| EP-0350694-A1 | Process for preparing n-acyl-phosphinothricine diesters | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-17 | — | — | EP | disclosed |
| EP-0009022-B1 | PROCESSES FOR PREPARING D,L-2-AMINO-4((HYDROXY)(METHYL)PHOSPHINOYL)-BUTYRIC ACID AND AN ACETAL OF AN ESTER OF 3-OXOPROPYLMETHYL PHOSPHINIC ACID | MEIJI SEIKA KAISHA LTD. (JP) | 1982-07-07 | — | — | EP | disclosed |
| US-4264532-A | REACTING A DIALKYL PHOSPHONITE WITH ACROLEIN; ESTERIFING AND THEN REACTING WITH POTASSIUM CYANIDE AND AMMONIUM CHLORIDE | MEIJI SEIKA KAISHA LTD. (JP) | 1981-04-28 | — | — | US | disclosed |
| EP-0009022-A1 | Processes for preparing D,L-2-amino-4((hydroxy)(methyl)phosphinoyl)-butyric acid and an acetal of an ester of 3-oxopropylmethyl phosphinic acid | MEIJI SEIKA KAISHA LTD. (JP) | 1980-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | TSHR 4568/4885TP53 946/4885TDP1 976/4885 |
| US-20110071101-A1 | Nucleoside Phosphonate Analogs | TYMP, PNP, NUDT1 | TSHR 3423/4885TP53 1353/4885TDP1 340/4885 |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | TSHR 4568/4885TP53 946/4885TDP1 976/4885 |
| US-20190284215-A1 | SIMPLE PREPARATION METHOD FOR DIALKOXYPROPYL METHYLPHOSPHONATE | PPIP5K2, PNKP, MPHOSPH6 | TSHR 2904/4885TP53 2550/4885TDP1 2866/4885 |
| US-10759818-B2 | Simple preparation method for dialkoxypropyl methylphosphonate | PPIP5K2, PNKP, MPHOSPH6 | TSHR 2904/4885TP53 2550/4885TDP1 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.