Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 2/20 | 0.36 |
| ▸ | PYGM | P11217 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23836089 | 0.74 | IDO1 (0.46) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL7310972 | 0.74 | IDO1 (0.46) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL12520453 | 0.71 | IDO1 (0.44) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL24740169 | 0.71 | IDO1 (0.48) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL24740261 | 0.71 | IDO1 (0.48) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL7012095 | 0.69 | KMT2A (0.41) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL10558578 | 0.69 | MAOB (0.40) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL9774486 | 0.69 | EGFR (0.38) | SLC6A2SLC6A3SLC6A4KMT2AMEN1 | |
| SCHEMBL20416267 | 0.67 | IDO1 (0.43) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL24019656 | 0.65 | HTR5A (0.45) | KMT2AMAPTMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |