Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HSD17B3 | P37058 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775143 | 0.87 | ALDH1A1 (0.58) | NPC1RAB9AKMT2APOLBMEN1 | |
| SCHEMBL9775156 | 0.86 | RAB9A (0.70) | NPC1RAB9AKMT2AMEN1THRA | |
| SCHEMBL9786927 | 0.81 | MEN1 (0.67) | HSP90AA1KCNH2NPC1RAB9AKMT2A | |
| SCHEMBL1951429 | 0.78 | HSP90AA1 (0.55) | HSP90AA1KCNH2NPC1RAB9AKMT2A | |
| SCHEMBL17131550 | 0.77 | HPGD (0.53) | NPC1RAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL417732 | 0.77 | ALDH1A1 (0.70) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL9419411 | 0.76 | KMT2A (0.69) | NPC1RAB9AHSD17B3KMT2AMEN1 | |
| SCHEMBL20578188 | 0.76 | HPGD (0.51) | NPC1RAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL417283 | 0.75 | NPC1 (0.43) | HSP90AA1NPC1RAB9AKMT2APOLB | |
| SCHEMBL416482 | 0.75 | ALDH1A1 (0.72) | HSP90AA1KCNH2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075339-A | Antiinflammatory agents, antiallergens | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-4948813-A | Benzylketone phospholipase A2 inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-08-14 | — | — | US | disclosed |