Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 9/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775608 | 1.00 | MAPT (0.46) | MAPTKMT2AMEN1TP53MAPK1 | |
| SCHEMBL9775580 | 0.79 | AKR1C1 (0.44) | MAPTKMT2AMEN1MAPK1RAB9A | |
| SCHEMBL9775578 | 0.79 | AKR1C1 (0.44) | MAPTKMT2AMEN1MAPK1RAB9A | |
| SCHEMBL1291055 | 0.76 | HDAC1 (0.58) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL10363546 | 0.71 | AKR1C3 (0.52) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL9775586 | 0.71 | AKR1C3 (0.52) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL28803434 | 0.71 | SMN1; SMN2 (0.43) | MAPTKMT2AMEN1TP53MAPK1 | |
| SCHEMBL5471581 | 0.71 | AKR1C1 (0.58) | MAPTKMT2AMEN1TP53MAPK1 | |
| SCHEMBL22279521 | 0.70 | RAB9A (0.54) | MAPTKMT2AMEN1TP53MAPK1 | |
| SCHEMBL7664129 | 0.69 | GLA (0.38) | MAPTKMT2AMEN1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987140-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | ROUSSEL UCLAF (FR) | 1991-01-22 | — | — | US | disclosed |
| US-4925859-A | Novel 4-hydroxy-3-pyridine-carboxamides useful for treating inflammation and rheumatism | ROUSSEL UCLAF (FR) | 1990-05-15 | — | — | US | disclosed |