Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775573 | 0.85 | RAB9A (0.50) | ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9775626 | 0.83 | RAB9A (0.49) | ALDH1A1MEN1LMNAKMT2AGAA | |
| SCHEMBL9775656 | 0.81 | NPC1 (0.51) | ALDH1A1MEN1LMNAKMT2ANFKB1 | |
| SCHEMBL9775636 | 0.76 | SMN1; SMN2 (0.55) | ALDH1A1MEN1LMNAKMT2AGAA | |
| SCHEMBL9775653 | 0.75 | MEN1 (0.46) | ALDH1A1MEN1LMNAKMT2AGAA | |
| SCHEMBL9775604 | 0.72 | RAB9A (0.49) | ALDH1A1MEN1LMNAKMT2AGAA | |
| SCHEMBL9775581 | 0.72 | NPC1 (0.48) | ALDH1A1MEN1LMNAKMT2AGAA | |
| SCHEMBL9775616 | 0.71 | RAB9A (0.50) | MEN1LMNAKMT2AGAAPOLB | |
| SCHEMBL31171374 | 0.66 | XPO1 (0.55) | XPO1MEN1KMT2AGAA | |
| SCHEMBL28869489 | 0.66 | AURKA (0.47) | XPO1ALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987140-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | ROUSSEL UCLAF (FR) | 1991-01-22 | — | — | US | claimed |
| US-4987140-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | ROUSSEL UCLAF (FR) | 1991-01-22 | — | — | US | disclosed |
| US-4925859-A | Novel 4-hydroxy-3-pyridine-carboxamides useful for treating inflammation and rheumatism | ROUSSEL UCLAF (FR) | 1990-05-15 | — | — | US | disclosed |