Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775695 | 0.89 | ALDH1A1 (0.60) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL9775609 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL9775683 | 0.87 | POLB (0.58) | SMN1; SMN2MAPTALDH1A1KDM4EGAA | |
| SCHEMBL9775535 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL399026 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL10370033 | 0.77 | KDM4E (0.49) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| Ammonia Solution, Strong SCHEMBL10370588 | 0.76 | KDM4E (0.48) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL9775599 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL28150311 | 0.76 | MAPT (0.55) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL9775627 | 0.76 | XPO1 (0.48) | LMNAALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987140-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | ROUSSEL UCLAF (FR) | 1991-01-22 | — | — | US | disclosed |
| US-4925859-A | Novel 4-hydroxy-3-pyridine-carboxamides useful for treating inflammation and rheumatism | ROUSSEL UCLAF (FR) | 1990-05-15 | — | — | US | disclosed |