Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.44 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775609 | 0.88 | SMN1; SMN2 (0.48) | POLBGAASMN1; SMN2TP53HTT | |
| SCHEMBL9775636 | 0.87 | SMN1; SMN2 (0.55) | POLBGAASMN1; SMN2TP53MAPT | |
| SCHEMBL9775695 | 0.77 | ALDH1A1 (0.60) | POLBGAASMN1; SMN2TP53HTT | |
| SCHEMBL11373065 | 0.76 | RORC (0.48) | POLBGAASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9775535 | 0.76 | ALDH1A1 (0.47) | POLBGAASMN1; SMN2TP53HTT | |
| SCHEMBL10370033 | 0.75 | KDM4E (0.49) | POLBGAASMN1; SMN2MAPTMEN1 | |
| SCHEMBL15665869 | 0.75 | GAA (0.51) | POLBGAASMN1; SMN2TP53MAPT | |
| SCHEMBL9775642 | 0.74 | RAB9A (0.56) | GAASMN1; SMN2TP53HTTMAPT | |
| SCHEMBL20507211 | 0.74 | HTT (0.53) | POLBGAASMN1; SMN2TP53HTT | |
| Ammonia Solution, Strong SCHEMBL10370588 | 0.73 | KDM4E (0.48) | POLBGAASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987140-A | ANTIINFLAMMATORY, ANTIRHEUMATIC | ROUSSEL UCLAF (FR) | 1991-01-22 | — | — | US | disclosed |
| US-4925859-A | Novel 4-hydroxy-3-pyridine-carboxamides useful for treating inflammation and rheumatism | ROUSSEL UCLAF (FR) | 1990-05-15 | — | — | US | disclosed |