Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775654 | 1.00 | DRD2 (0.62) | DRD2DRD4HTR1AKDM4EALDH1A1 | |
| SCHEMBL8446436 | 0.80 | HTR1A (0.53) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8446435 | 0.80 | HTR1A (0.53) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8446460 | 0.79 | DRD2 (0.85) | DRD2DRD4HTR1AADRA1A | |
| Hydrochloric Acid SCHEMBL9775640 | 0.78 | DRD2 (0.83) | DRD2DRD4HTR1AADRA1A | |
| SCHEMBL11626341 | 0.78 | RECQL (0.68) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL30547268 | 0.78 | RECQL (0.68) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8609924 | 0.77 | MAPT (0.62) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL12304200 | 0.77 | DRD2 (0.66) | DRD2DRD4HTR1AKDM4EALDH1A1 | |
| SCHEMBL8943531 | 0.77 | HTR1A (0.66) | DRD2HTR1AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | claimed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | disclosed |