Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775867 | 0.90 | KDM4E (0.69) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9775941 | 0.89 | KDM4E (0.56) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9526209 | 0.89 | KDM4E (0.68) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9775905 | 0.88 | KDM4E (0.49) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| Water SCHEMBL9775975 | 0.88 | KDM4E (0.67) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9775910 | 0.88 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL9094359 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL9097124 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL8941960 | 0.86 | DPP4 (0.49) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL8942340 | 0.86 | DPP4 (0.54) | ALDH1A1KDM4ELMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |