Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941959 | 0.89 | ADRB2 (0.43) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9775862 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL8942057 | 0.87 | ADRB2 (0.49) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL8941953 | 0.87 | ADRB2 (0.45) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9775869 | 0.86 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL7231247 | 0.84 | ADRB2 (0.46) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9775934 | 0.84 | KMT2A (0.46) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL29576777 | 0.83 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9638922 | 0.83 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL8942248 | 0.83 | ADRB2 (0.41) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |