Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775920 | 0.88 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9775910 | 0.86 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL8942074 | 0.86 | KMT2A (0.46) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL8941916 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9786124 | 0.84 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7228015 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9775973 | 0.78 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7235505 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL8942039 | 0.78 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9775958 | 0.77 | STAT3 (0.44) | KDM4EALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |