Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL28902214 | 0.69 | TSHR (0.42) | TSHR | |
| Isopropyl Alcohol SCHEMBL14686032 | 0.68 | ALDH1A1 (0.50) | CA4CA2CA1FAHD1 | |
| Bicarbonate SCHEMBL1065466 | 0.67 | CA1 (0.50) | CA4TSHRCA2CA1FAHD1 | |
| Bicarbonate SCHEMBL3706559 | 0.67 | TSHR (0.78) | CA4TSHRCA2CA1CA12 | |
| Potassium Ion SCHEMBL6360383 | 0.65 | — | — | |
| Oxalic Acid SCHEMBL1052682 | 0.64 | CA4 (0.58) | CA4TSHRCA2CA1FAHD1 | |
| Bicarbonate SCHEMBL3895350 | 0.63 | — | — | |
| Bicarbonate SCHEMBL2275798 | 0.62 | CA4 (0.67) | CA4CA2CA1CA12CA9 | |
| Bicarbonate SCHEMBL28420909 | 0.62 | CA4 (0.67) | CA4CA2CA1CA12CA9 | |
| Bicarbonate SCHEMBL852 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5076847-A | Reaction product of titanium ortho-ester, glycol or glycol eth er, alkanolamine, alpha-hydroxy carboxy acid and base | TIOXIDE GROUP PLC (GB) | 1991-12-31 | — | — | US | claimed |