SCHEMBL9777965

SCHEMBL9777965

O=C(O)CCc1ccc(C(O)CNS(=O)(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.63
TBXA2R P21731 5/20 0.57
MAPT P10636 1/20 0.54
NPSR1 Q6W5P4 1/20 0.52
TBXAS1 P24557 7/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9778033 0.89 ALDH1A1 (0.64) ALDH1A1TBXA2RMAPTNPSR1TBXAS1
SCHEMBL9777998 0.88 TBXA2R (0.64) ALDH1A1TBXA2RMAPTNPSR1TBXAS1
SCHEMBL9777961 0.84 ALDH1A1 (0.61) ALDH1A1TBXA2RMAPTNPSR1TBXAS1
SCHEMBL9660518 0.83 TBXA2R (0.66) ALDH1A1TBXA2RMAPTTBXAS1
SCHEMBL10464014 0.82 TBXA2R (0.69) ALDH1A1TBXA2RMAPTTBXAS1
SCHEMBL9130164 0.82 TBXA2R (0.81) ALDH1A1TBXA2RMAPTTBXAS1
SCHEMBL10591985 0.80 CA1 (0.54) ALDH1A1MAPTNPSR1TBXAS1
SCHEMBL10591996 0.80 CA1 (0.54) ALDH1A1MAPTNPSR1
SCHEMBL9777989 0.80 TBXA2R (0.49) ALDH1A1TBXA2RMAPTNPSR1TBXAS1
SCHEMBL24590667 0.79 CA1 (0.56) ALDH1A1MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4999345-A Anticoagulants BASF AKTIENGESELLSCHAFT (DE) 1991-03-12 US disclosed
EP-0345572-A2 Sulfonamide derivatives, their preparation and pharmaceuticals containing them BASF Aktiengesellschaft (DE) 1989-12-13 EP disclosed