Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9778470 | 0.91 | HTR6 (0.48) | MAT2AHTR6KDM4EALDH1A1GAA | |
| SCHEMBL9778410 | 0.86 | HTR6 (0.48) | MAT2AHTR6POLBDRD2HTR1A | |
| SCHEMBL1544859 | 0.86 | HTT (0.43) | MAT2AHTR6KDM4EALDH1A1GAA | |
| SCHEMBL1544929 | 0.86 | HTR6 (0.56) | HTR6POLBDRD2HTR1AHTR2A | |
| SCHEMBL9778505 | 0.80 | HTR6 (0.48) | HTR6HTTPOLBDRD2HTR1A | |
| SCHEMBL9778550 | 0.78 | HTR6 (0.54) | HTR6POLBGBA1 | |
| SCHEMBL9681923 | 0.77 | MAT2A (0.65) | MAT2AHTR6KDM4EALDH1A1GAA | |
| SCHEMBL14140342 | 0.73 | HTR6 (0.54) | HTR6POLBDRD2HTR1AHTR2A | |
| SCHEMBL5103496 | 0.73 | HTR6 (0.54) | HTR6POLBDRD2HTR1AHTR2A | |
| SCHEMBL5253182 | 0.73 | CNR1 (0.47) | HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | claimed |
| US-5077405-A | Condensation of corresponding phenylsulfonyl compound with condensation agent, cyanation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0417653-A1 | 3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | disclosed |