SCHEMBL9780319

SCHEMBL9780319

CN1CCCN(S(=O)(=O)c2ccc3c(c2)Cc2cc(Br)ccc2-3)CC1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.57
PKM P14618 3/20 0.56
KMT2A Q03164 1/20 0.54
CYP2C19 P33261 1/20 0.54
APOBEC3A P31941 1/20 0.52
APOBEC3G Q9HC16 1/20 0.52
POLB P06746 1/20 0.51
ALDH1A1 P00352 1/20 0.48
HTT P42858 1/20 0.46
ATM Q13315 1/20 0.46
BRD4 O60885 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KDM4E B2RXH2 1/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9780231 0.99 RAB9A (0.60) RAB9APKMKMT2ACYP2C19APOBEC3A
SCHEMBL16026507 0.87 ATM (0.58) RAB9APKMKMT2APOLBHTT
SCHEMBL9780219 0.85 L3MBTL1 (0.46) RAB9APKMKMT2APOLBALDH1A1
SCHEMBL2836256 0.82 KMT2A (0.72) RAB9APKMKMT2ACYP2C19APOBEC3A
SCHEMBL9780225 0.81 HTR2C (0.55) PKMALDH1A1BRD4
Iodide SCHEMBL9780276 0.81 BRD4 (0.42) RAB9APKMPOLBALDH1A1HTT
Iodide SCHEMBL9780273 0.81 BRD4 (0.42) RAB9APKMPOLBALDH1A1HTT
SCHEMBL3430555 0.80 APOBEC3A (0.67) RAB9APKMKMT2ACYP2C19APOBEC3A
SCHEMBL1156725 0.76 ATM (0.69) KMT2AAPOBEC3AAPOBEC3GPOLBALDH1A1
Hydrochloric Acid SCHEMBL9780304 0.74 AKR1C3 (0.43) KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5030631-A Hypotensive, bronchodilator agents SCHERING CORPORATION (US) 1991-07-09 US claimed