Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780596 | 0.87 | MEN1 (0.55) | MEN1KMT2AMRGPRX4MAOBFFAR1 | |
| SCHEMBL18179855 | 0.82 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL2209201 | 0.79 | MEN1 (0.51) | MEN1KMT2AMRGPRX4MAOBFFAR1 | |
| SCHEMBL2203344 | 0.79 | MAOB (0.49) | L3MBTL1MAPK1MEN1KMT2AMRGPRX4 | |
| SCHEMBL4852083 | 0.78 | MEN1 (0.56) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL1137350 | 0.78 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1MAPK1MAOBFFAR1 | |
| SCHEMBL2658123 | 0.77 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MAPK1MAOBFFAR1 | |
| SCHEMBL20867886 | 0.77 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MAPK1MAOBFFAR1 | |
| SCHEMBL28207459 | 0.77 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MAPK1MAOBFFAR1 | |
| SCHEMBL597702 | 0.77 | MEN1 (0.63) | MEN1KMT2AMRGPRX4MAOBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |