Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | SLC26A3 | P40879 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780850 | 0.87 | ALDH1A1 (0.57) | MEN1KMT2AFFAR1MRGPRX4MAOB | |
| SCHEMBL2203344 | 0.82 | MAOB (0.49) | MEN1KMT2AFFAR1MRGPRX4MAOB | |
| SCHEMBL2209201 | 0.82 | MEN1 (0.51) | MEN1KMT2AFFAR1MRGPRX4MAOB | |
| SCHEMBL3914337 | 0.82 | S1PR1 (0.60) | MEN1KMT2AFFAR1MRGPRX4MAOB | |
| SCHEMBL597702 | 0.81 | MEN1 (0.63) | MEN1KMT2AFFAR1MRGPRX4MAOB | |
| SCHEMBL9205498 | 0.80 | LTB4R (0.68) | MEN1KMT2ALTB4RLTB4R2FFAR1 | |
| SCHEMBL2957881 | 0.80 | MEN1 (0.67) | MEN1KMT2ALTB4RLTB4R2FFAR1 | |
| SCHEMBL11965262 | 0.79 | MAOB (0.54) | MEN1KMT2APTGDR2LTB4RLTB4R2 | |
| SCHEMBL20781419 | 0.79 | MAOB (0.54) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL16348239 | 0.79 | MEN1 (0.65) | MEN1KMT2ALTB4RLTB4R2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |