Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.71 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780865 | 1.00 | HSD11B1 (0.71) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL6907589 | 0.85 | NFKB1 (0.50) | HSD11B1BCHEKMT2ACA1CA2 | |
| SCHEMBL17973990 | 0.83 | HSD11B1 (1.00) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL30317482 | 0.83 | HSD11B1 (1.00) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL18458918 | 0.83 | HSD11B1 (0.50) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL18416813 | 0.83 | HSD11B1 (0.50) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL1049717 | 0.82 | HSD11B1 (0.74) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL1049718 | 0.82 | HSD11B1 (0.74) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL1479957 | 0.80 | HSD11B1 (0.71) | HSD11B1BCHELY96KMT2AATM | |
| SCHEMBL1782824 | 0.80 | HSD11B1 (0.71) | HSD11B1BCHELY96KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |