Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400152 | 0.79 | CTRB1 (0.48) | MMP8NPC1RAB9ALMNAMEN1 | |
| SCHEMBL5544627 | 0.78 | NPC1 (0.53) | MMP8NPC1RAB9ALMNATAAR1 | |
| SCHEMBL11076699 | 0.74 | NPC1 (0.49) | MMP8NPC1RAB9ALMNACTRB1 | |
| SCHEMBL4509037 | 0.71 | MMP8 (0.46) | TSHRMMP8NPC1RAB9A | |
| SCHEMBL21925496 | 0.71 | TSHR (0.51) | TSHR | |
| SCHEMBL13915938 | 0.71 | TSHR (0.48) | TSHRMMP8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16732121 | 0.71 | TSHR (0.40) | TSHRMMP8RAB9ALMNAMEN1 | |
| SCHEMBL25982910 | 0.71 | ALPI (0.53) | TSHRMMP8 | |
| SCHEMBL26023598 | 0.71 | ALPI (0.53) | TSHRMMP8 | |
| SCHEMBL9395003 | 0.70 | SMN1; SMN2 (0.48) | MMP8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988714-A | Drugs for treatment of obesity and diabetics, increases protein breakdown, for fattening animals | HOFFMANN-LA ROCHE INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4800206-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-01-24 | — | — | US | disclosed |