4,4'-Dimethoxychalcone

4,4'-Dimethoxychalcone

SCHEMBL978243

COc1ccc(C=CC(=O)c2ccc(OC)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 2/20 1.00
MAOB P27338 9/20 0.87
MAPT P10636 4/20 0.87
MAOA P21397 4/20 0.87
XDH P47989 2/20 0.87
MEN1 O00255 2/20 0.87
ALDH1A1 P00352 2/20 0.87
KMT2A Q03164 2/20 0.87
P4HB P07237 1/20 0.87
CALM1 P0DP23 1/20 0.87
RAB9A P51151 1/20 0.87
NPC1 O15118 1/20 0.84
LMNA P02545 1/20 0.84
CYP1B1 Q16678 3/20 0.84
TNFRSF1A P19438 3/20 0.84
HSPD1 P10809 1/20 0.84
HSPE1 P61604 1/20 0.84
BCHE P06276 1/20 0.84
CYP3A4 P08684 1/20 0.84
NFKB1 P19838 1/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4,4'-Dimethoxychalcone SCHEMBL978242 1.00 F3 (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL11478555 0.93 XDH (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL3889361 0.93 MAPT (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL3889363 0.93 MAPT (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL25194802 0.93 MAPT (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL25191319 0.93 XDH (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL25189143 0.93 MAPT (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL25191040 0.93 F3 (0.87) F3MAOBMAPTMAOAXDH
SCHEMBL14307274 0.93 MAOB (1.00) F3MAOBMAPTMAOAXDH
SCHEMBL25201206 0.93 F3 (0.87) F3MAOBMAPTMAOAXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250177337-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS ON BONE HEALTH NESTLE SA (CH) 2025-06-05 US claimed
CN-115400106-B Application of natural compound and composition thereof in removing aging cells 清华大学 2024-01-19 CN claimed
CN-113564103-B Application of 4,4' -dimethoxy chalcone in delaying in-vitro and in-vivo aging of oocyte 南京医科大学 2023-01-06 CN claimed
CN-115400106-A Application of natural compound and composition thereof in removing senescent cells 清华大学 2022-11-29 CN claimed
US-20220296550-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS NESTLE SA (CH) 2022-09-22 US claimed
US-20220184015-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS ON BONE HEALTH NESTLE SA (CH) 2022-06-16 US claimed
CN-114557931-A Whitening, moisturizing and anti-saccharification composition, preparation method and application thereof 上海自易品牌管理有限公司 2022-05-31 CN claimed
EP-3986557-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS Société des Produits Nestlé S.A. (CH) 2022-04-27 EP claimed
CN-113908096-A Whitening, moisturizing and anti-saccharification composition, preparation method and application thereof 上海自易品牌管理有限公司 2022-01-11 CN claimed
CN-113564103-A Application of 4, 4' -dimethoxy chalcone in delaying in-vitro and in-vivo aging of oocyte 南京医科大学 2021-10-29 CN claimed
WO-2020254664-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS Société des Produits Nestlé S.A. (CH) 2020-12-24 WO claimed
JP-4279568-A None JP disclosed
US-20260015573-A1 LACTIPLANTIBACILLUS PLANTARUM EL6 FOR INCREASING FLAVONOID CONTENT, AND USE THEREOF CHINA AGRICULTURAL UNIVERSITY (CN) 2026-01-15 US disclosed
US-20250177337-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS ON BONE HEALTH NESTLE SA (CH) 2025-06-05 US disclosed
US-20250177337-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS ON BONE HEALTH NESTLE SA (CH) 2025-06-05 US disclosed
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
EP-0540604-A1 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS Aventis Pharma S.A. (FR) 1993-05-12 EP disclosed
JP-H04279568-A PYRIDINE DERIVATIVE MITSUBISHI KASEI CORP 1992-10-05 JP disclosed
WO-1992001675-A2 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS RHONE-POULENC RORER S.A. (FR) 1992-02-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015573-A1 LACTIPLANTIBACILLUS PLANTARUM EL6 FOR INCREASING FLAVONOID CONTENT, AND USE THEREOF MGAM, RPL6, LPO F3 1758/4885MAOB 2218/4885MAPT 4519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.