SCHEMBL145787

SCHEMBL145787

COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 1.00
F3 P13726 3/20 1.00
XDH P47989 2/20 1.00
MEN1 O00255 2/20 1.00
ALDH1A1 P00352 2/20 1.00
KMT2A Q03164 2/20 1.00
P4HB P07237 1/20 1.00
CALM1 P0DP23 1/20 1.00
RAB9A P51151 1/20 1.00
MAOB P27338 9/20 0.77
MAOA P21397 3/20 0.77
NPC1 O15118 1/20 0.75
LMNA P02545 1/20 0.75
CYP1B1 Q16678 3/20 0.74
HSPD1 P10809 1/20 0.74
TNFRSF1A P19438 1/20 0.74
HSPE1 P61604 1/20 0.74
BCHE P06276 1/20 0.74
CYP3A4 P08684 1/20 0.74
NFKB1 P19838 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25194802 1.00 MAPT (1.00) MAPTF3XDHMEN1ALDH1A1
SCHEMBL3889363 1.00 MAPT (1.00) MAPTF3XDHMEN1ALDH1A1
SCHEMBL3889361 1.00 MAPT (1.00) MAPTF3XDHMEN1ALDH1A1
SCHEMBL25189143 1.00 MAPT (1.00) MAPTF3XDHMEN1ALDH1A1
SCHEMBL145788 1.00 MAPT (1.00) MAPTF3XDHMEN1ALDH1A1
4,4'-Dimethoxychalcone SCHEMBL978243 0.93 F3 (1.00) MAPTF3XDHMEN1ALDH1A1
4,4'-Dimethoxychalcone SCHEMBL978242 0.93 F3 (1.00) MAPTF3XDHMEN1ALDH1A1
SCHEMBL25199635 0.88 F3 (0.78) MAPTF3XDHMEN1ALDH1A1
SCHEMBL25221620 0.88 F3 (0.78) MAPTF3XDHMEN1ALDH1A1
SCHEMBL11471612 0.88 MAPT (0.78) MAPTF3XDHMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-20260013312-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR NIKON CORPORATION (JP) 2026-01-08 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
CN-119954731-A Chalcone derivative containing 4-quinazolinone structure, and preparation method and application thereof 黔南州烟草公司平塘县分公司 2025-05-09 CN disclosed
WO-2025069235-A1 COMPOUND, PHOTOSENSITIVE SURFACE TREATMENT AGENT, LAMINATE PRODUCTION METHOD, AND TRANSISTOR PRODUCTION METHOD 株式会社ニコン 2025-04-03 WO disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
WO-2024189876-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR 株式会社ニコン 2024-09-19 WO disclosed
WO-2024189875-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR 株式会社ニコン 2024-09-19 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
US-20100093955-A1 PHOTOREACTIVE POLYMER AND METHOD FOR PREPARING THE SAME LG CHEM, LTD. (KR) 2010-04-15 US disclosed
US-20090181324-A1 PHOTOSENSITIVE POLYIMIDES ETERNAL CHEMICAL CO., LTD. 2009-07-16 US disclosed
WO-2008115028-A1 PHOTOREACTIVE POLYMER AND METHOD FOR PREPARING THE SAME LG CHEM, LTD. (KR) 2008-09-25 WO disclosed
US-20070128658-A1 FLUORESCENT DYES, METHODS AND USES THEREOF WISCONSIN ALUMNI RESEARCH FOUNDATION 2007-06-07 US disclosed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US disclosed
US-20030104145-A1 Chemical adsorbent and liquid crystal alignment layer utilizing the same and liquid crystal display device utilizing the same and methods of manufacturing them MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 2003-06-05 US disclosed
US-6495221-B1 EXTREMELY THIN AND TRANSPARENT FILM IN NANOMETER ORDER; HYDROCHALCONE DERIVATIVE SUBSTITUTED WITH A ISOCYANATOSILYL GROUP MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 2002-12-17 US disclosed
EP-0962460-A1 CHEMISORPTIVE SUBSTANCE, ALIGNED LIQUID-CRYSTAL FILM AND LIQUID-CRYSTAL DISPLAY ELEMENT BOTH MADE BY USING THE SAME, AND PROCESSES FOR PRODUCING THESE MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1999-12-08 EP disclosed
US-5525457-A Copolymers of unsaturated carboxylic acid, an epoxy-functional monomer, and cinnamoylphenyl group-monomer; high halation preventing effect, involves no sublimation of radiation absorbing components contained therein, possesses excellent heat resistance, dry etching performance, storage stability JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1996-06-11 US disclosed
US-4584190-A AROMATIC, UNSATURATED, OXO, OXYESTER KAO CORPORATION (JP) 1986-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030104145-A1 Chemical adsorbent and liquid crystal alignment layer utilizing the same and liquid crystal display device utilizing the same and methods of manufacturing them UACA, CRYAA, CUTA MAPT 46/4885F3 876/4885XDH 510/4885
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885F3 5/4885XDH 1328/4885
US-20260013312-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR ICMT, PIGT, PORCN MAPT 340/4885F3 783/4885XDH 3965/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885F3 11/4885XDH 1963/4885
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents LIPC, CYP46A1, HMGCR MAPT 4801/4885F3 1338/4885XDH 1425/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885F3 11/4885XDH 1963/4885
US-20100093955-A1 PHOTOREACTIVE POLYMER AND METHOD FOR PREPARING THE SAME PCNA, LCP1, CCND2 MAPT 103/4885F3 2050/4885XDH 4171/4885
US-20070128658-A1 FLUORESCENT DYES, METHODS AND USES THEREOF DHX15, DHX35, DUT MAPT 3454/4885F3 2344/4885XDH 2450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.