Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 15/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 13/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.51 |
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | MITF | O75030 | 6/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981321 | 0.84 | RAB9A (0.48) | HTTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1372817 | 0.83 | HTT (0.56) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL9237405 | 0.83 | HTT (0.50) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL31735821 | 0.81 | ALDH1A1 (0.54) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL9234092 | 0.81 | HTT (0.57) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL14574536 | 0.80 | HTT (0.56) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL10360715 | 0.79 | HTT (0.54) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL2361037 | 0.78 | HTT (0.54) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL9763242 | 0.77 | HTT (0.55) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL10884770 | 0.77 | HTT (0.53) | HTTALDH1A1SMN1; SMN2RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025245484-A1 | FOXN1 ACTIVATORS | THYMOFOX INC. (US) | 2025-11-27 | — | — | WO | disclosed |
| EP-2456765-B1 | IMIDAZOLE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-05-01 | — | — | EP | disclosed |
| US-8334287-B2 | Imidazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-12-18 | — | — | US | disclosed |
| EP-2456765-A1 | IMIDAZOLE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011006910-A1 | IMIDAZOLE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-20 | — | — | WO | disclosed |
| US-20110015202-A1 | IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015202-A1 | IMIDAZOLES | GRM5, GRM1, GRIK5 | HTT 1711/4885ALDH1A1 1642/4885SMN1; SMN2 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.