Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PGK1 | P00558 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786413 | 0.80 | KMT2A (0.62) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 | |
| SCHEMBL9786404 | 0.77 | KMT2A (0.42) | MEN1KMT2APOLBPDE10A | |
| SCHEMBL1879752 | 0.76 | IMPDH2 (0.53) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10555220 | 0.73 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 | |
| SCHEMBL10562491 | 0.72 | ALDH1A1 (0.60) | SMN1; SMN2PGK1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9374588 | 0.71 | CREBBP (0.34) | SMN1; SMN2KMT2APOLBTP53PDE10A | |
| SCHEMBL22792298 | 0.70 | CYP1A2 (0.53) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 | |
| SCHEMBL6287057 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 | |
| SCHEMBL6285841 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 | |
| SCHEMBL6286928 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2APGK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036088-A | Enzyme inhibitors; cyclooxygenase, lipoxygenase | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-5006541-A | Antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904685-A | Antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4835166-A | LIPOXYGENASE, CYCLOOXYGENASE INHIBITORS | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |