Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.62 |
| ▸ | ATP4A | P20648 | 10/20 | 0.64 |
| ▸ | ATP4B | P51164 | 10/20 | 0.64 |
| ▸ | EBP | Q15125 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9789063 | 0.99 | ATP4A (0.63) | ATP4AATP4BEBPSIGMAR1ROCK2 | |
| SCHEMBL9789001 | 0.80 | ATP4A (0.61) | ATP4AATP4BEBPSIGMAR1ROCK2 | |
| SCHEMBL2397911 | 0.79 | ATP4A (0.65) | ATP4AATP4BEBPSIGMAR1RAB9A | |
| SCHEMBL9789069 | 0.77 | ATP4A (0.65) | ATP4AATP4BROCK1RAB9AMAPK1 | |
| Hydrochloric Acid SCHEMBL9788958 | 0.77 | ATP4A (0.66) | ATP4AATP4BROCK1RAB9AMAPK1 | |
| Bromide SCHEMBL9788992 | 0.76 | ATP4A (0.70) | ATP4AATP4BEBPSIGMAR1 | |
| SCHEMBL9789065 | 0.75 | ATP4A (0.63) | ATP4AATP4BROCK2ROCK1RAB9A | |
| SCHEMBL8974700 | 0.74 | ROCK1 (0.47) | ATP4AATP4BROCK2ROCK1RAB9A | |
| SCHEMBL9788980 | 0.73 | ATP4A (0.63) | ATP4AATP4BROCK2ROCK1RAB9A | |
| Hydrochloric Acid SCHEMBL10454848 | 0.73 | ROCK1 (0.46) | ATP4AATP4BROCK2ROCK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0259085-A1 | 2-Guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1988-03-09 | — | — | EP | disclosed |