Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.58 |
| ▸ | ATP4A | P20648 | 16/20 | 0.70 |
| ▸ | ATP4B | P51164 | 16/20 | 0.70 |
| ▸ | EBP | Q15125 | 1/20 | 0.58 |
| ▸ | ADA | P00813 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9788956 | 0.78 | ATP4A (0.72) | ATP4AATP4B | |
| Bromide SCHEMBL9788994 | 0.76 | ATP4A (0.64) | ATP4AATP4BEBPSIGMAR1 | |
| SCHEMBL9789063 | 0.74 | ATP4A (0.63) | ATP4AATP4BEBPSIGMAR1 | |
| SCHEMBL9011521 | 0.69 | MAPT (0.59) | ATP4AATP4BADAHRH2HRH4 | |
| SCHEMBL9011519 | 0.69 | MAPT (0.59) | ATP4AATP4BADAHRH2HRH4 | |
| SCHEMBL9258494 | 0.69 | RAB9A (0.41) | ATP4AATP4BSIGMAR1HRH2HRH4 | |
| SCHEMBL9258485 | 0.69 | RAB9A (0.41) | ATP4AATP4BSIGMAR1HRH2HRH4 | |
| SCHEMBL1807649 | 0.69 | ATP4A (0.65) | ATP4AATP4BEBPSIGMAR1 | |
| SCHEMBL9789059 | 0.68 | ATP4A (0.53) | ATP4AATP4BEBPSIGMAR1ADA | |
| SCHEMBL12157310 | 0.68 | ATP4A (0.75) | ATP4AATP4BHRH2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259085-B1 | 2-GUANIDINO-4-ARYLTHIAZOLES FOR TREATMENT OF PEPTIC ULCERS | PFIZER INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |