Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.51 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899767 | 0.92 | ALOX5AP (0.55) | ALOX5APESR1ESR2ALOX5HSD11B1 | |
| SCHEMBL12920588 | 0.82 | ALOX5AP (0.56) | ALOX5APESR2ALOX5HSD11B1 | |
| SCHEMBL12920599 | 0.82 | ALOX5AP (0.56) | ALOX5APESR2ALOX5HSD11B1 | |
| SCHEMBL12920590 | 0.82 | ALOX5AP (0.56) | ALOX5APESR2ALOX5HSD11B1 | |
| SCHEMBL790026 | 0.75 | ALOX5AP (0.45) | ALOX5APHSD11B1LMNATDP1 | |
| SCHEMBL12286910 | 0.75 | ALOX5AP (0.51) | ALOX5APESR1ESR2ALOX5HSD11B1 | |
| SCHEMBL12954721 | 0.74 | ALOX5AP (0.63) | ALOX5APESR1ESR2ALOX5HSD11B1 | |
| SCHEMBL259032 | 0.74 | ALOX5AP (0.63) | ALOX5APESR1ESR2ALOX5HSD11B1 | |
| SCHEMBL12948105 | 0.74 | ALOX5AP (0.56) | ALOX5APESR2ALOX5HSD11B1KMT2A | |
| SCHEMBL2247662 | 0.69 | ALOX5AP (0.45) | ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003815-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | MERCK & CO., INC. | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003815-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES | PTGIS, PTGS1, LTC4S | ALOX5AP 47/4885ESR1 3802/4885ESR2 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.