Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058804 | 0.87 | ELANE (0.32) | ELANEPLAUHSD17B10TSHRKDM4E | |
| SCHEMBL11082200 | 0.85 | ELANE (0.32) | ELANEPLAUHSD17B10TSHRKDM4E | |
| SCHEMBL9792191 | 0.84 | HTT (0.41) | ELANEPLAUTSHRKDM4EALDH1A1 | |
| SCHEMBL9792203 | 0.84 | KMT2A (0.40) | ELANETSHRHPGDLMNA | |
| SCHEMBL9792252 | 0.82 | HPGD (0.43) | ALDH1A1HPGDTAS1R3TAS1R1LMNA | |
| SCHEMBL9792318 | 0.80 | HPGD (0.45) | TSHRKDM4EALDH1A1GAAHPGD | |
| SCHEMBL9792312 | 0.80 | TAS1R3 (0.41) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL9792213 | 0.80 | TAS1R3 (0.40) | ELANEPLAUKDM4EALDH1A1HPGD | |
| SCHEMBL9689339 | 0.79 | MEN1 (0.36) | ELANEPLAUHSD17B10TSHRALDH1A1 | |
| SCHEMBL9792307 | 0.78 | SMN1; SMN2 (0.40) | HSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |