Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792252 | 0.90 | HPGD (0.43) | HTTHPGDLMNAVNN1MEN1 | |
| SCHEMBL9792203 | 0.90 | KMT2A (0.40) | HTTHPGDL3MBTL1ELANEACHE | |
| SCHEMBL9792234 | 0.88 | HPGD (0.40) | HTTHPGDL3MBTL1HRH3LDHA | |
| SCHEMBL9792312 | 0.87 | TAS1R3 (0.41) | ALDH1A1 | |
| SCHEMBL11060324 | 0.87 | HTT (0.37) | HTTHPGDL3MBTL1HRH3LDHA | |
| SCHEMBL11057482 | 0.86 | HTT (0.38) | HTTHPGDL3MBTL1HRH3LDHA | |
| SCHEMBL9792189 | 0.84 | ELANE (0.34) | HPGDPLAUELANELMNAKDM4E | |
| SCHEMBL9792251 | 0.83 | CYP1A2 (0.49) | HTTL3MBTL1LMNATDP1KDM4E | |
| SCHEMBL9792213 | 0.82 | TAS1R3 (0.40) | HTTHPGDF2PLAUELANE | |
| SCHEMBL9792307 | 0.81 | SMN1; SMN2 (0.40) | HPGDTDP1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |