Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792191 | 0.90 | HTT (0.41) | HPGDLMNAHTTALDH1A1KMT2A | |
| SCHEMBL9792203 | 0.88 | KMT2A (0.40) | HPGDLMNANPSR1HTTKMT2A | |
| SCHEMBL9792312 | 0.85 | TAS1R3 (0.41) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL9792189 | 0.82 | ELANE (0.34) | HPGDLMNAALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL9792234 | 0.81 | HPGD (0.40) | HPGDLMNAHTTALDH1A1KMT2A | |
| SCHEMBL9792213 | 0.81 | TAS1R3 (0.40) | HPGDLMNANPSR1HTTALDH1A1 | |
| SCHEMBL9792318 | 0.79 | HPGD (0.45) | HPGDLMNANPSR1ALDH1A1KMT2A | |
| SCHEMBL9792307 | 0.79 | SMN1; SMN2 (0.40) | HPGDALDH1A1KMT2AMAPTRAB9A | |
| SCHEMBL9792210 | 0.78 | KMT2A (0.34) | HPGDALDH1A1KMT2AMAPTRAB9A | |
| SCHEMBL11060324 | 0.78 | HTT (0.37) | HPGDLMNAHTTMAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |