Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275552 | 0.95 | SLC6A4 (0.59) | HTR1AHTR1DHTR1BSLC6A4 | |
| Hydrochloric Acid SCHEMBL9764443 | 0.86 | SLC6A4 (0.61) | SLC6A4 | |
| SCHEMBL4541937 | 0.84 | SLC6A4 (0.61) | SLC6A4 | |
| SCHEMBL9772971 | 0.80 | SLC6A4 (0.59) | SLC6A4 | |
| Hydrochloric Acid SCHEMBL9772910 | 0.80 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL14207477 | 0.79 | SLC6A4 (0.53) | HTR1ASLC6A4 | |
| SCHEMBL12015468 | 0.78 | HTR6 (0.45) | HTR1AHTR1DHTR1B | |
| SCHEMBL15292058 | 0.76 | SLC6A4 (0.60) | SLC6A4 | |
| SCHEMBL14207392 | 0.76 | SLC6A4 (0.56) | SLC6A4 | |
| SCHEMBL7809897 | 0.76 | SLC6A4 (0.69) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |