SCHEMBL1275552

SCHEMBL1275552

CNS(=O)(=O)CCc1ccc2[nH]cc(C3=CCN(C)CC3)c2c1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 7/20 0.59
HTR1A P08908 1/20 0.59
HTR1D P28221 1/20 0.59
HTR1B P28222 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxalic Acid SCHEMBL9793607 0.95 HTR1A (0.55) SLC6A4HTR1AHTR1DHTR1B
Hydrochloric Acid SCHEMBL9764443 0.90 SLC6A4 (0.61) SLC6A4
SCHEMBL4541937 0.88 SLC6A4 (0.61) SLC6A4
SCHEMBL9772971 0.84 SLC6A4 (0.59) SLC6A4
Hydrochloric Acid SCHEMBL9772910 0.84 SLC6A4 (0.59) SLC6A4
SCHEMBL12015468 0.82 HTR6 (0.45) HTR1AHTR1DHTR1B
SCHEMBL14207477 0.81 SLC6A4 (0.53) SLC6A4HTR1A
SCHEMBL15292058 0.80 SLC6A4 (0.60) SLC6A4
SCHEMBL7809897 0.80 SLC6A4 (0.69) SLC6A4
SCHEMBL3379399 0.80 SLC6A4 (0.71) SLC6A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010004580-A2 PROCESS FOR PREPARING INDOLE DERIVATIVES IND-SWIFT LABORATORIES LIMITED (IN) 2010-01-14 WO claimed
WO-2009016466-A2 A PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) 2009-02-05 WO claimed
US-8735589-B2 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2014-05-27 US disclosed
US-8735589-B2 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2014-05-27 US disclosed
US-8735589-B2 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2014-05-27 US disclosed
EP-2467373-B1 A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN CIPLA LTD (IN) 2013-10-02 EP disclosed
EP-2467373-B1 A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN CIPLA LTD (IN) 2013-10-02 EP disclosed
US-20120220778-A1 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2012-08-30 US disclosed
US-20120220778-A1 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2012-08-30 US disclosed
US-20120220778-A1 Process for the synthesis of naratriptan CIPLA LIMITED (IN) 2012-08-30 US disclosed
EP-2467373-A2 A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN Cipla Limited (IN) 2012-06-27 EP disclosed
WO-2011021000-A2 A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN CIPLA LIMITED (IN) 2011-02-24 WO disclosed
WO-2011021000-A2 A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN CIPLA LIMITED (IN) 2011-02-24 WO disclosed
WO-2009016466-A2 A PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) 2009-02-05 WO disclosed
WO-2009016466-A2 A PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) 2009-02-05 WO disclosed
WO-2008072257-A2 PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES IND-SWIFT LABORATORIES LIMITED (IN) 2008-06-19 WO disclosed
WO-2008056378-A2 NOVEL PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE NATCO PHARMA LIMITED (IN) 2008-05-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120220778-A1 Process for the synthesis of naratriptan ZFR, SPR, NPSR1 SLC6A4 32/4885HTR1A 318/4885HTR1D 547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.