Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CASP1 | P29466 | 2/20 | 0.98 |
| ▸ | TP53 | P04637 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | ESR1 | P03372 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | NQO2 | P16083 | 1/20 | 0.98 |
| ▸ | MAOA | P21397 | 1/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | MAOB | P27338 | 1/20 | 0.98 |
| ▸ | PDE4A | P27815 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Primaquine SCHEMBL29409423 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL12599100 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL22208 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL22207 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL4959404 | 0.98 | KDM4E (0.98) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL6333949 | 0.98 | KDM4E (0.98) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL9240759 | 0.95 | KDM4E (0.92) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL4954948 | 0.94 | KDM4E (0.90) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL41097 | 0.93 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL29576219 | 0.93 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871808-B2 | Isolated microorganism having an ability to produce L-histidine | KYOWA HAKKO BIO CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| EP-1085086-B1 | Method for producing L-histidine by fermentation using DNA gyrase inhibitor resistant bacterial strains | KYOWA HAKKO KOGYO KK (JP) | 2008-03-19 | — | — | EP | disclosed |
| EP-1085087-B1 | Method for producing L-histidine by fermentation using aminoquinoline resistant bacterial strains of the genus Escherichia | KYOWA HAKKO KOGYO KK (JP) | 2007-06-20 | — | — | EP | disclosed |
| US-20060194302-A1 | Method for producing amino acids by fermentation | KYOWA HAKKO BIO CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |
| US-7067289-B1 | Method for producing histidine by fermentation with E. coli | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-06-27 | — | — | US | disclosed |
| US-6706517-B2 | GENERATING HISTIDINE IN BACTERIAL CULTURE; OBTAIN MICROORGANISM CAPABLE OF GENERATING HISTIDINE, CULTURE, RECOVER HISTIDINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20020102665-A1 | Method for producing L-amino acids by fermentation | KYOWA HAKKO BIO CO., LTD. (JP) | 2002-08-01 | — | — | US | disclosed |
| US-6344347-B1 | PRODUCING L-HISTIDINE FROM A MUTANT ESCHERICHIA MICROORGANISM USING ULTRAVIOLET IRRADIATION AND TREATMENT WITH A MUTAGEN, THEN CULTURE THE MUTANT CELLS ON AGAR PLATES CONTAINING A DNA GYRASE INHIBITOR TO PREVENT PARENT STRAIN FROM GROWING | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-02-05 | — | — | US | disclosed |
| EP-1085087-A2 | Method for producing amino acids by fermentation using aminoquinoline resistant bacterial strains | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |
| EP-1085086-A2 | Method for producing amino acids by fermentation using DNA gyrase inhibitor resistant bacterial strains | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |